Лопать взрывчатку, чтобы похудеть и согреться!

[dmm]

Скотт Александр написал прелестную статью про историю изумительно вредной гадости (2,4-Динитрофенол), которая вполне успешно работает в качестве таблетки для похудения ("если выживешь, то похудеешь, но, может быть, ещё ослепнешь"). Удивительно, что правительства так и не смогли её вполне запретить, и особо одарённый народ продолжает её жрать mostly for bodybuilding purposes и травиться.

Теперь, разумеется, всякий biotech пытается сделать более безопасную версию этой штуки.

"It next shows up in history books on the Eastern Front of World War 2, where Soviet soldiers would - I can’t believe I’m writing this - take it to keep warm. There’s something quintessentially Russian about this, like a cross between the Platonic essences of AK-47s and Krokodil."

Ссылки и другие яркие цитаты - в комментариях.

Comments

[dmm]

https://astralcodexten.substack.com/p/shilling-for-big-mitochondria

https://en.wikipedia.org/wiki/2,4-Dinitrophenol

[dmm]

"DNP is that rarest of birds: a weight-loss pill which really works, no diet or exercise required. About 100,000 people used it in the mid-1930s. On average, they lost about 2 to 5 pounds per week, for however many weeks they wanted to keep losing it. The formula stayed popular until it was banned by the FDA in 1938, about one second after Congress passed the law saying the FDA could ban things."

[dmm]

"As far as I know, DNP is the only substance to be banned by both the FDA and the Department of Homeland Security for unrelated reasons."

[dmm]

"“Normal” DNP users will run a slight fever. But people who overdose will get fevers of 110 degrees (Fahrenheit) plus, which are incompatible with life. This is very rare[...]"

[dmm]

"Whenever British tabloids, Vice, and the FDA all hate a thing, I’m inclined to feel at least a little fondness towards it."

[dmm]

"A friend of mine works there and shilled his company hard enough to get me interested in this."

He is such a good writer - style, and everything.

Меж тем, как написано в русской википедии: "ДНФ является высокотоксичным соединением. [...] С другой стороны, лабораторные мыши или крысы, которые всю жизнь получали небольшие дозы ДНФ, имеют большую продолжительность жизни."

https://pubmed.ncbi.nlm.nih.gov/18505478/

"Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity." Aging Cell (2008) Aug 7(4):552-60

Abstract: "Caloric restriction is the most effective non-genetic intervention to enhance lifespan known to date. A major research interest has been the development of therapeutic strategies capable of promoting the beneficial results of this dietary regimen. In this sense, we propose that compounds that decrease the efficiency of energy conversion, such as mitochondrial uncouplers, can be caloric restriction mimetics. Treatment of mice with low doses of the protonophore 2,4-dinitrophenol promotes enhanced tissue respiratory rates, improved serological glucose, triglyceride and insulin levels, decrease of reactive oxygen species levels and tissue DNA and protein oxidation, as well as reduced body weight. Importantly, 2,4-dinitrophenol-treated animals also presented enhanced longevity. Our results demonstrate that mild mitochondrial uncoupling is a highly effective in vivo antioxidant strategy, and describe the first therapeutic intervention capable of effectively reproducing the physiological, metabolic and lifespan effects of caloric restriction in healthy mammals."

Такие дела...

[ya_miranda]

Интересная таблеточка) чтобы согреться)
"Кто они такие, что пьют ракетное топливо?" (с)

[dmm]

https://twitter.com/slatestarcodex/status/1366841501402079233

"Nominative determinism that didn't quite make it into today's post on sketchy diet pills: the scientists who discovered 2,4-DNP were named Cutting and Tainter."