A possible anti-aging breakthrough
Jul. 8th, 2024 08:57 am![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
dmm"Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice"
A Feb 24 paper seems to claim an impressive result in "wild-type" mice via a partial cellular reprogramming protocol, which includes cyclic administration of doxycycline for temporal control of reprogramming, and which does not seem to be particularly cancer-inducing (that's usually a big problem with cellular reprogramming).. 124-week male mice, Doxycycline-treated controls average survival till 133 weeks, treatment group average survival till 142.5 weeks (for a human something like this would roughly double remaining life expectancy of a 75-year old male from about 10 more years to about 20 more years if equally efficient).
It would be nice if this turns out to be a real breakthrough (we have learned from experience to be very skeptical about claims in this field of study).
A Feb 24 paper seems to claim an impressive result in "wild-type" mice via a partial cellular reprogramming protocol, which includes cyclic administration of doxycycline for temporal control of reprogramming, and which does not seem to be particularly cancer-inducing (that's usually a big problem with cellular reprogramming).. 124-week male mice, Doxycycline-treated controls average survival till 133 weeks, treatment group average survival till 142.5 weeks (for a human something like this would roughly double remaining life expectancy of a 75-year old male from about 10 more years to about 20 more years if equally efficient).
It would be nice if this turns out to be a real breakthrough (we have learned from experience to be very skeptical about claims in this field of study).
no subject
Date: 2024-07-08 01:00 pm (UTC)no subject
Date: 2024-07-08 01:01 pm (UTC)no subject
Date: 2024-07-18 12:59 am (UTC)Inhibition of IL-11 signalling extends mammalian healthspan and lifespan, https://www.nature.com/articles/s41586-024-07701-9
https://x.com/bryan_johnson/status/1813710102308028577
https://x.com/EricTopol/status/1813595738120810537
(One should always be skeptical about all this, but this one is also promising.)